Oct 19, - I've heard that the Food and Drug Administration has issued cautions about diabetes drugs Avandia and Actos. Avandia and Actos — which belong to a class of drugs known as thiazolidinediones — are two of many oral medications designed to control blood sugar in those with. Sep 5, - Still, pioglitazone works so well in older patients that, in my judgment, the Patients who take pioglitazone also should do a couple of simple. Jan 12, - Actos tablets contain the active ingredient pioglitazone How does it work? doctor prescribes depends on how well your blood sugar is controlled and what other Do not take a double dose to make up for a missed dose.